Mesa (TRT) Testosterone Replacement Therapy

The Amazing Effect TRT Has on Type 2 Diabetes

Recent research has shed light on a potentially transformative treatment for men with Type 2 diabetes. A study led by the University at Buffalo has found that testosterone therapy can lead to remission of the condition in a significant number of patients. This groundbreaking discovery could revolutionize the way we approach diabetes treatment.

TRT Leads To Remission of Type 2 Diabetes

Recent Study on TRT and Type 2 Diabetes

The study, conducted over 11 years in Bremerhaven, Germany, found that testosterone therapy reversed Type 2 diabetes in one-third of the study participants. Paresh Dandona, SUNY Distinguished Professor in the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at UB, co-authored the study.

  • It was a single-site study conducted over 11 years
  • Testosterone therapy reversed Type 2 diabetes in one-third of the participants
  • The study was co-authored by Paresh Dandona, a distinguished professor at UB

Hypogonadism in Type 2 Diabetes

The discovery of this syndrome of hypogonadism in Type 2 diabetes was made by Dandona’s group at UB in 2004. This group then extended the prevalence of this syndrome to include 25% of non-diabetic obese men in 2010. Thus, diabetes and obesity became the main cause of male hypogonadism. The group went on to demonstrate that such patients have additional insulin resistance that reverses with testosterone treatment in 2016.

Key points to remember about hypogonadism:

  • Hypogonadism is common in men with Type 2 diabetes
  • Diabetes and obesity are the main causes of male hypogonadism
  • Testosterone treatment can reverse additional insulin resistance in these patients

A New Approach to Diabetes Treatment

The objective of the researchers’ study was to determine if men with Type 2 diabetes who also exhibit hypogonadism, when treated with testosterone in addition to their regular diabetes treatment, would demonstrate improved glycemic control and insulin sensitivity, and possibly eventually experience remission of Type 2 diabetes.

  • The study aimed to determine if testosterone treatment could improve glycemic control and insulin sensitivity
  • The researchers also wanted to see if testosterone treatment could lead to remission of Type 2 diabetes

A Promising Outcome

The results showed that the men treated with testosterone had “significant progressive and sustained reductions in their body weight, fasting glucose, HbA1c and fasting insulin over the treatment period,” the authors wrote. In the control group, fasting glucose, HbA1c and fasting insulin increased.

Key points to remember about the study’s results:

  • Men treated with testosterone saw significant reductions in body weight, fasting glucose, HbA1c, and fasting insulin
  • One-third of men treated with testosterone saw remission of their diabetes

TRT: A New Horizon in Diabetes Management

The research indicates that long-term treatment with testosterone is potentially a novel additional therapy for men with Type 2 diabetes and hypogonadism. Going forward, prospective randomized controlled trials are needed to confirm the data. One such trial is currently in progress.

  • Long-term testosterone treatment could be a novel therapy for men with Type 2 diabetes and hypogonadism
  • Further trials are needed to confirm the data

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